Hypoxia signaling during intestinal ischemia and inflammation
نویسندگان
چکیده
منابع مشابه
Nitric oxide interferes with hypoxia signaling during colonic inflammation.
CONTEXT Intestinal inflammation can induce a local reduction in oxygen levels that triggers an adaptive response centered on the expression of hypoxia-inducible factors (HIFs). Nitric oxide, a well-described inflammatory mediator, may interfere with hypoxia signaling. OBJECTIVES We aimed to evaluate the role of nitric oxide in hypoxia signaling during colonic inflammation. METHODS Colitis w...
متن کاملThe role of hypoxia in intestinal inflammation
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestine. IBD is a multifactorial disorder, and IBD-associated genes are critical in innate immune response, inflammatory response, autophagy, and epithelial barrier integrity. Moreover, epithelial oxygen tension plays a critical role in intestinal inflammation and resolution in IBD. The intestines have a dynam...
متن کاملYou can't run from inflammation: lower extremity ischemia, hypoxia signaling, and macrophage subtypes.
Work done by many investigators over the last decade has shed light onto the mechanisms of oxygen sensing in cells and in organisms.1 The prolyl hydroxylase domain (PHD; also called EglN) proteins belong to a family of Fe(II) and 2-oxoglutarate–dependent dioxygenases, whose activity depends on oxygen bioavailability.2 One well-described substrate of PHDs is the master transcription factor hypox...
متن کاملIntestinal tachyarrhythmias during small bowel ischemia.
The electrical control activity (ECA) of the bowel is the omnipresent slow electrical wave of the intestinal tract. Characterization of small bowel electrical activity during ischemia may be used as a measure of intestinal viability. With the use of an animal model of mesenteric ischemia, serosal electrodes and a digital recording apparatus utilizing autoregressive spectral analysis were used t...
متن کاملCrosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation.
During intestinal inflammation, a variety of signaling events are activated to perform several cell functions. Although the distinct roles of these pathways have been elucidated, the effects of their crosstalk activities remain to be clarified. We evaluated the crosstalk between two evolutionary conserved cell signaling systems, toll-like-receptor (TLR) 5 and Notch1, in intestinal epithelial ce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Critical Care
سال: 2012
ISSN: 1070-5295
DOI: 10.1097/mcc.0b013e3283514bd0